Based on the Saturday morning cartoon show of the same name, Toxic Crusaders gives the player a chance to take on the role of nerd janitor-turned-superhero Toxie as he battles the evil and injustice inflicted upon humanity by the dastardly alien supervillian, Dr. Killemoff. Toxie is armed with his trusty mop, an effective weapon in his hands which can be made even more powerful with special power-ups. Toxie and his Toxic Crusaders move through six different game levels as they work to clean the streets of Killemoff's foul and deadly pollution, keeping the city safe for all its good citizens.